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FSH受体Asn680Ser多态度调节卵巢内氧化的生物利用性和IVF期间的卵巢响应性

Charalampos Voros¹, Diamantis Athanasiou¹, Despoina Mavrogianni¹

¹First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.

International journal of molecular sciences

|March 14, 2026

概括

毛囊刺激激素受体 (FSHR) Asn680Ser多态性影响体外受精 (IVF) 的结果. 具有Ser/Ser基因型的女性表现出更好的卵细胞产量和受精率,这可能与氧化的生物可用性有关.

科学领域:

生殖内分泌学生殖内分泌学
遗传学遗传学是一个
在体外受精 (IVF)

背景情况:

个体卵巢反应的变化在试管婴儿期间对受控的卵巢刺激提出了挑战.
卵泡刺激激素受体 (FSHR) Asn680Ser多态性影响卵巢对FSH的敏感性.
毛囊内氧化还原信号,特别是氧化物 (NO) 在这种多态性方面所起的作用尚不清楚.

研究的目的:

在接受试管婴儿的妇女中,研究FSHR Asn680Ser多态性和卵泡内氧化代谢物 (NO2-NO3) 之间的关联.
为了比较不同FSHR基因组之间的卵巢反应指标,激素概况和受精结果.

主要方法:

根据FSHR Asn680Ser基因型,前性观察性研究将接受试管婴儿的女性分为Asn等位基载体 (Asn/Asn,Asn/Ser) 和Ser/Ser同胞体.
评估毛囊液中NO2-NO3度,卵巢反应标志物,荷尔蒙水平和受精率.

主要成果:

两组之间没有观察到基线或触发日激素水平的显著差异.
与Asn等位基携带者相比,Ser/Ser同位基呈现出明显更高的总卵细胞数和更多的基相II卵细胞.
在Ser/Ser组中,受精结果得到改善,并趋向于增加卵泡内NO2-NO3度,尽管这没有达到统计学意义.

结论:

FSHR Asn680Ser多态性与IVF中的卵巢反应差异有关.
FSH受体的遗传变异可能会影响毛囊功能能力和毛囊内氧化的生物可用性,影响试管婴儿成功率.

关键词:

Asn680Ser的多态性多态性在FSH受体中,FSH受体是最重要的.在这个过程中,IVF IVF.不孕症不孕不育不孕不育不孕不育氧化氧化的使用方法

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