国家依赖的DNA甲基化特征区分急性和稳定的冠状动脉综合征
Işık Tekin1, Alten Oskay2, Tülay Oskay3
1Department of Cardiology, Faculty of Medicine, Pamukkale University, 20160 Denizli, Türkiye.
International journal of molecular sciences
|March 14, 2026
概括
在急性冠状动脉综合征 (ACS) 和稳定冠状动脉综合征 (SCS) 之间,DNA甲基化模式显著不同. 这些独特的表观遗传特征突出显示了冠状动脉疾病急性和进展的潜在分子标志物.
科学领域:
- 心血管表观遗传学 心血管表观遗传学
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 冠状动脉疾病 (CAD) 表现为稳定性 (SCS) 和急性 (ACS) 综合征.
- 表观遗传因素,如DNA甲基化,与CAD进展和斑块不稳定有关.
- 在ACS,SCS和对照组之间,全基因组甲基化差异的综合性尚不完全理解.
研究的目的:
- 研究全基因组DNA甲基化差异在ACS,SCS和健康个体.
- 确定与急性冠状动脉综合征和稳定的冠状动脉综合征相关的独特表观遗传特征.
- 探索DNA甲基化在CAD病原和疾病急性中的作用.
主要方法:
- 在患有ACS,SCS和健康对照患者身上进行了全基因组DNA甲基化分析.
- 进行了对对比 (ACS与对照,SCS与对照,ACS与SCS).
- 使用逻辑回归 (methylKit包,R) 用严格的统计标准 (q值<0.05, 度>20%) 确定了差异甲基化区域.
主要成果:
- 无监督的等级聚类揭示了分离ACS,SCS和对照样本的明显表观遗传特征.
- 与对照组相比,ACS表现出比SCS更显著的甲基化变化.
- 途径分析表明,在ACS中增加了应激反应,细胞亡和细胞粘附途径,在SCS中增加了细胞间通信/血管信号.
结论:
- 急性和稳定的冠状动脉综合征具有不同的DNA甲基化格局和相关的通路签名.
- 压力,粘附和信号通路的表观遗传调节可能会影响CAD的敏度和进展.
- DNA甲基化代表了区分CAD状态和预测疾病轨迹的潜在分子标记物.
更多相关视频
13:47Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
Published on: February 24, 2015
26.5K
13:21Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
10.6K
相关概念视频
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
620
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
620
Acute Coronary Syndrome III: Diagnostic Studies
369
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
369
Acute Coronary Syndrome I: Introduction
1.4K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.4K
Epigenetic Regulation
4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
4.1K
Epigenetic Regulation
34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
