通过纸张喷雾质谱仪对酸进行快速分析
Ping Guo1,2, Sijie Zhu1,2, Bo Chen1,2
1Key Laboratory of Phytochemical R&D of Hunan Province, Hunan Normal University, No. 36, Lushan Road, Changsha 410081, China.
Molecules (Basel, Switzerland)
|March 14, 2026
概括
一种新方法使用三甲基二甲 (TMSD) 衍生和纸喷雾质谱法 (PS-MS) 快速量化植物酸 (PA). 这种技术克服了质谱学的挑战,使复杂样品的精确分析成为可能.
科学领域:
- 分析化学 分析化学
- 质谱测量质量谱测量
- 食品科学 食品科学 食品科学
背景情况:
- 酸 (PA) 在质谱学中存在量化挑战,原因是矩阵效应和复杂的添加物形成.
- 准确和快速的PA量化对于食品和植物产品的质量控制至关重要.
研究的目的:
- 为酸 (PA) 开发一种快速,灵敏和强大的定量方法.
- 克服传统质谱技术在PA分析方面的局限性.
主要方法:
- 使用三甲基西利迪亚佐米 (TMSD) 来衍生植物酸 (PA),形成稳定的甲基衍生物 (PA-Me).
- 纸喷雾质谱法 (PS-MS) 用于快速分析,没有染色学分离.
- 净化涉及气吹倒,然后进行水复合,以减少背景干扰.
主要成果:
- 开发的方法在0.125-30μg/mL的度范围内显示出良好的线性 (R2 ≥0.9965).
- 达到0.080μg/mL的检测极限 (LOD) 和0.270μg/mL的量化极限 (LOQ).
- 显示了高精度 (<10% RSD) 和恢复率 (87.2%-122.4%),在米样本中得到验证.
结论:
- 与PS-MS相结合的TMSD衍生提供了一个快速的,无LC的分析策略,用于植物酸量化.
- 该方法为分析复杂的食品和植物矩阵中的PA提供了可靠的解决方案,支持质量控制.
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