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Updated: Mar 15, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

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一种新型的沃贡因衍生物通过向线粒体功能障碍并激活ROS-p38/MAPK通路来诱导PC-3M细胞的亡

Dingrui Liu1, Fangfei Liu1, Mingjie Song1

  • 1College of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.

Molecules (Basel, Switzerland)
|March 14, 2026
PubMed
概括

米托-WO-8是一种新型的沃贡因衍生物,有效地准癌细胞线粒体,通过ROS-p38/MAPK通路增强功效并诱导亡. 这种改进的线粒体药物递送提供了癌症治疗的有希望的策略.

关键词:
在PC-3M中使用.在ROS-p38/MAPK路径中.灭症 (apoptosis) 是一种死亡的过程.线粒体向的目标是线粒体在Wogonin中的Wogonin.

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