调节血糖控制的Vaccinium myrtillus 叶子提取物:因素联合管理的影响
Jelena Živković1, Slavica Ristić2, Saša Petričević2
1Institute for Medicinal Plants Research "Dr. Josif Pančić", Tadeuša Košćuška 1, 11000 Belgrade, Serbia.
Foods (Basel, Switzerland)
|March 14, 2026
概括
白叶提取物 (VME) 和其富含胰岛素的形式 (VMEI) 显示出管理高血糖的潜力. 在小鼠中,VMEI表现出增强的酶抑制和降糖效应,表明其作为2型糖尿病功能性食物的承诺.
科学领域:
- 植物化学和药理学
- 营养科学和功能性食品
背景情况:
- 传统上使用的Vaccinium myrtillus L. (胡桃) 叶用于高血糖管理.
- 蓝多和胰岛素对代谢健康的联合作用的有限表征.
- 功能性食品在2型糖尿病管理中的潜力.
研究的目的:
- 评估白叶提取物 (VME) 和其素丰富配方 (VMEI) 的抗高血糖作用.
- 调查VME和VMEI作为2型糖尿病的功能性食品成分.
- 评估体外酶抑制和体内疗效和毒性.
主要方法:
- 高性能液体色谱 (HPLC) 用于化合物分析.
- 在体外酶抑制试验 (α-氨基酶,α-葡萄糖酶).
- 在Caenorhabditis elegans的体内毒性评估.
- 在食高脂肪,高糖 (HFHS) 饮食的小鼠中进行了为期三个月的饮食干预.
主要成果:
- 酸被确定为VME的主要化合物;VMEI显示出更强的α-葡萄糖酶抑制.
- 鲁丁和过氧化物对α-氨酶和α-葡萄糖酶表现出显著的抑制活性.
- 在C. elegans中,VME表现出中度毒性;这两种提取物都减少了运动.
- 在HFHS养的小鼠中,VME和VMEI都显著降低了血糖水平,而VMEI显示出更明显的效应.
结论:
- 蓝叶多结合胰岛素可以增强体外酶抑制.
- 在体内结果表明VMEI对代谢健康的潜在抗高血糖作用.
- 需要进一步的研究来探索VMEI作为2型糖尿病管理的功能性食品.
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