在更年期前的焦虑中肠道微生物群:通过饮食的新治疗途径
Giuseppe Marano1,2, Claudia d'Abate3, Ilaria Ianes3
1Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Nutrients
|March 14, 2026
概括
绝经前期的焦虑可能与肠道微生物群的变化有关. 针对肠道微生物组的饮食干预措施有望改善更年期期间的情感福祉,但需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 内分泌学 在内分泌学.
背景情况:
- 绝经前期涉及荷尔蒙波动增加焦虑的脆弱性.
- 雌激素的下降会影响肠道微生物群,影响神经免疫和神经内分泌通路.
- 肠道微生物群的改变与更年期过渡期间的情绪调节有关.
研究的目的:
- 审查在绝经前期期间肠道微生物群的变化.
- 评估食策略,以向微生物群-肠-大脑机制来治疗更年期前期的焦虑.
- 综合有关更年期饮食,微生物群和焦虑的证据.
主要方法:
- 在PubMed,Scopus和科学网上进行文献搜索.
- 包括临床,转化和临床前研究.
- 叙事综合,重点关注生物可信性和临床相关性.
主要成果:
- 绝经前期与微生物多样性和有益细菌 (例如,乳酸菌,双菌) 的减少有关.
- 微生物群的变化与增加的肠道透性,炎症和HPA轴调节障碍相关.
- 饮食干预措施 (地中海饮食,纤维,益生菌) 调节微生物群,并可能减少焦虑.
结论:
- 肠道失调有助于通过免疫,代谢和神经内分泌途径导致绝经前期的焦虑.
- 肠道微生物群的饮食调节是情绪健康的可信补充方法.
- 进一步的绝经前期特异性试验至关重要,以确认基于微生物组的营养策略的有效性.
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