饮食叶酸与前列腺癌之间的关联 非洲裔美国人和欧洲裔美国人的前列腺癌攻击性
Lihchyun Joseph Su1, Sarah O'Connor1, Daniela Ramirez Aguilar2
1Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Nutrients
|March 14, 2026
概括
叶酸的摄入可能会增加前列腺癌的攻击性在非洲裔美国人男性,而减少在欧洲裔美国人男性. 叶酸来源和种族显著改变了这一关联,影响了预防前列腺癌的营养指南.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 有关合成叶酸 (叶酸) 促进癌症进展存在担忧,尽管它在预防神经管缺陷方面的作用.
- 这项研究调查了非洲裔美国人 (AA) 和欧洲裔美国人 (EA) 男性的叶酸摄入量和前列腺癌 (PCa) 攻击性之间的关系.
研究的目的:
- 评估不同来源的叶酸摄入量和前列腺癌的攻击性之间的关联.
- 为了确定这种关联是否受到种族的修改.
主要方法:
- 包括722名AA和775名EA男性被诊断患有前列腺癌.
- 叶酸摄入量 (DFE,合成,天然) 通过调查问卷进行评估.
- 后勤回归分析了叶酸摄入量和PCa的攻击性,对种族进行了相互作用效应的测试.
主要成果:
- 在AA男性中,攻击性PCa的发病率 (31.6%) 比EA男性 (21.7%) 高.
- 饮食中叶酸等效 (DFE) 摄入量下降与两组PCa攻击性有关.
- 最高的合成叶酸摄入量与AAs中较高的PCa攻击性几率相关 (adj. OR = 1.39),但EA的几率较低 (adj. 或是 = 0.62).
结论:
- 叶酸与前列腺癌攻击性的关联是源特定的,并且取决于种族.
- 结果表明需要量身定制的营养建议,强调PCa进展中的营养素-基因和饮食相互作用.
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