果实提取物缓解慢性异常性便秘并改善肠道功能:单心,随机,双盲,安慰剂控制的临床试验
Maria Vittoria Morone1, Gaia Spadarella2, Alessandro Di Minno1
1Department of Pharmacy, University of Napoli Federico II, 80131 Naples, Italy.
海棘水果提取物有效治疗慢性异常性便秘 (CIC). 这项研究发现,肠道排便有显著改善,并减少了胃肠道症状,没有副作用,提供了安全的替代疗法.
科学领域:
- 胃肠病学 胃肠病学
- 药物鉴定学是指药物鉴定学.
- 临床营养学 临床营养学
背景情况:
- 慢性异常性便秘 (CIC) 影响全球14%,不成比例地影响女性和老年人.
- 现有的CIC治疗方法往往缺乏有效性,需要新的治疗方法.
- 海 (Hippophae rhamnoides L.) 是一种植物性生物活性化合物的来源,具有潜在的健康益处.
研究的目的:
- 评估Hippophae rhamnoides水果提取物在被诊断为CIC的成年人中的有效性和耐受性.
- 评估海提取物对自发性全肠排便 (SCBMs) 和胃肠道症状严重性的影响.
- 为了确定与海提取物补充相关的安全概况和生活质量变化.
主要方法:
- 这是一项为期28天的随机,双盲,安慰剂对照试验,涉及90名患有CIC的成年参与者.
- 参与者每天接受500毫克Hippophae rhamnoides水乙醇果实提取物或安慰剂.
- 测量结果包括SCBM频率的变化,便一致性 (布里斯托尔便形式尺度),胃肠道症状和生活质量 (SF-12).
主要成果:
- 与安慰剂相比,Hippophae rhamnoides提取物显著增加了每周SCBM频率 (p < 0.001) 和正常化便一致性 (p < 0.001).
- 在治疗组中报告了膨胀,腹痛和重度的显著减少.
- 没有观察到任何不良事件或救援药物的使用,这表明耐受性良好.
结论:
- Hippophae rhamnoides水果提取物在治疗慢性异常性便秘方面表现出显著的有效性和安全性.
- 海提取物为CIC提供了一个有希望的,耐受性良好,基于植物的治疗选择.
- 进一步的研究可能会探索海棘对胃肠道健康的长期影响和最佳剂量.
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