来自野生朱的新型多糖化物 (ZJP-2) 缓解神经干细胞的氧化损伤:结构特征和生物活性
Shilan Li1, Qiting Zhang2, Jixian Liu1
1Zhejiang-Pakistan Joint Laboratory on R&D of Herbal Medicines, Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China.
Nutrients
|March 14, 2026
概括
来自野生朱的一种新型素多糖化物 (ZJP-2) 显示出神经保护作用. 它通过降低活性氧物种和调高抗氧化基因,减少神经干细胞中的氧化应激.
科学领域:
- 药理学和天然产品化学化学
- 神经科学和干细胞生物学
背景情况:
- 野生朱 (Ziziphus jujuba Mill.) 是一种植物. 这里是 Var. Var. 的位置. (spinosa) 的传统用途是镇定精神,并被认为具有抗氧化和神经保护性质.
- 现代研究强调了朱提取物在增强认知功能和减轻炎症方面的潜力.
- 这项研究的重点是分离和表征果多糖因其在神经干细胞 (NSC) 中抗氧化应激的神经保护能力.
研究的目的:
- 从野生朱树中分离并阐明一种新型多糖的结构.
- 评估隔离的多糖分离体对神经干细胞 (NSCs) 中氧化应激的神经保护作用.
- 研究ZJP-2在NSC中的保护作用的潜在机制.
主要方法:
- 从野生朱树中分离和净化一个pectin多糖化物 (ZJP-2).
- 使用HPLC-MALS-RI,HPAEC,GC-MS和NMR光谱学的详细结构特征.
- 评估ZJP-2在C17.2神经干细胞 (NSC) 中对DMNQ诱导的氧化应激的保护作用.
主要成果:
- 鉴定ZJP-2是一种pectin异多聚糖化物 (大约. 67.93 kDa) 含有丰富的银河酸,阿拉比诺斯,拉姆诺斯,银河糖和葡萄糖.
- 结构分析揭示了RG-I域与特定的糖化链接,由NMR证实.
- ZJP-2显著降低了细胞内活性氧物种 (ROS),高调抗氧化剂基因表达,并抑制了NSC中的Nestin/NeuN过度表达,保持了它们的不分化状态.
结论:
- 孤立的多糖ZJP-2表现出独特的结构特征和强大的神经保护作用对抗氧化应激.
- ZJP-2在维持神经干细胞平衡和氧化损伤下的功能方面表现出潜力.
- ZJP-2 是一个有前途的候选人,可以作为功能性食品或食补充剂来预防神经退行.
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