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维生素D状态和败血症结果:一个符合PRISMA的总体审查和元分析
Gracia Castro-Luna1, Henar Gómez Galera2, Meritxell Sánchez Martínez2
1Department of Nursing, Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain.
Nutrients
|March 14, 2026
概括
维生素D缺乏与败血症风险和严重程度的增加有关,特别是在儿童中. 然而,维生素D补充剂并不能始终减少重症患者的败血症结果.
科学领域:
- 关键护理医学 关键护理医学
- 营养免疫学 营养免疫学
- 遗传学 遗传学 是一个
背景情况:
- 维生素D对免疫功能至关重要.
- 缺乏与感染易感性和严重疾病的不良结果有关.
- 现有的关于维生素D,VDR基因多态和败血症的研究是分散的.
研究的目的:
- 对维生素D状态,VDR基因多态,补充和败血症的高水平证据进行总体审查.
- 综合有关败血症发病率,死亡率,严重程度和遗传关联的证据.
- 遵守PRISMA 2020系统审查指南.
主要方法:
- 系统性审查和元分析 (2014-2025) 的综合性审查.
- 在PubMed,PubMed Central和期刊档案中进行搜索.
- 包括成人,儿科和新生儿人口;数据的定性综合.
主要成果:
- 维生素D缺乏与败血症风险,死亡率和严重程度的增加密切相关.
- 在儿科和新生儿群体中,相关性更为明显.
- 维生素D补充剂对败血症风险或死亡率没有明显的益处.
结论:
- 维生素D缺乏是败血症风险,严重程度和预后的重要指标.
- 目前的证据不支持维生素D补充剂用于治疗已确定的败血症.
- 进一步的研究可能会澄清VDR基因多态化在败血症易感性中的作用.
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