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血清25-基维生素D与年轻成年人血压之间的关联
Ching-Way Chen1,2, Shu-Yu Tang2, Yin-Yi Han3,4
1Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100229, Taiwan.
Nutrients
|March 14, 2026
概括
年轻人的维生素D水平较高与血压略低有关. 这项针对台湾年轻人的研究证实了血清25-基维生素D和血压指数之间的适度反向关联.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 营养科学 营养科学
背景情况:
- 观察性研究表明,维生素D和血压在整个寿命之间存在联系.
- 然而,研究结果不一致,效应大小通常很小.
- 在年轻人中,这种关联需要进一步研究.
研究的目的:
- 为了检查血清25-氧维生素D [25(OH) D]度与血压指数之间的关联.
- 在一个基于社区的年轻成年人群中调查这些关联.
主要方法:
- 对台湾年轻成年人 (YOTA) 队列的横截面分析 (n=923,年龄18-45岁).
- 血清25(OH) D连续和分类地建模.
- 使用标准化协议测量血压指数 (SBP,DBP,MAP).
- 多变量线性回归与对共变量进行序列调整;受限制的立方线被评估为非线性.
主要成果:
- 较高的血清25(OH) D度与较低的SBP,DBP和MAP相适度和线性相关.
- 每增加10 ng/mL的血清25(OH) D与1.07 mmHg较低的SBP,1.19 mmHg较低的DBP和1.22 mmHg较低的MAP相关.
- 关联在敏感性和子组分析中保持一致.
结论:
- 较高的血清25 ((OH) D度与年轻成年人血压降低有轻微的相关性.
- 这些发现证实了先前的观察证据,并将其扩展到健康的年轻成年人群中.
- 需要前性研究来澄清时间性和临床相关性.
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