伟成精减少了急性肠道阻塞的炎症
Ying Gong1, Zi-Hua Xuan1, Yue Dong1
1College of Pharmacy, Anhui University of Chinese Medicine, No. 350 Longzihu Road, Xinzhan District, Hefei, 230012, Anhui, China, ahtcm.edu.cn.
Mediators of inflammation
|March 14, 2026
概括
在急性肠道阻塞 (AIO) 模型中,Zengwei Chengqi Decoction (ZW) 有效地减少炎症和组织损伤. 这项研究突出了ZWW.
科学领域:
- 传统中国医药 传统中国医药
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 急性肠道阻塞 (AIO) 带来了重大的临床挑战.
- 炎症和组织损伤是AIO的关键病理特征.
- 对AIO的新型治疗剂的探索至关重要.
研究的目的:
- 在AIO中调查伟成奇 (ZW) 的治疗潜力.
- 阐明AIO中ZW的抗炎和组织保护机制.
- 利用网络药理学和动物模型来探索ZW的作用.
主要方法:
- 网络药理学在ZW中确定了228种活性化合物和420种与炎症相关的标.
- 进行了基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 途径分析.
- 建立了AIO的体内大鼠模型,以评估ZW对组织损伤和血清细胞因子的影响.
主要成果:
- 在AIO大鼠中,ZW治疗显著减轻了组织组织损伤.
- 血清中促炎性细胞因子 (IL-1β,IL-6,TNF-α) 的水平通过ZW显著降低.
- 对于细胞因子水平降低的p < 0.01观察到统计学意义.
结论:
- 在AIO中,Zengwei Chengqi Decoction (ZW) 显示出显著的抗炎作用.
- ZW改善了组织完整性,并减少了AIO中的关键的促炎媒介.
- ZW是治疗急性肠道阻塞的有希望的候选药物.
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