在控制不良的HIV患者中表观遗传衰老加速和死亡率
David W Sosnowski1, Chang Shu2, Hsing-Yu Hsu3
1Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
概括
艾滋病毒感染加速生物衰老,增加了注射毒品的人的死亡风险. 解决分子衰老问题对于减少这一脆弱群体的死亡率至关重要.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒感染与加速衰老和增加死亡率有关.
- 表观遗传年龄,生物年龄的衡量标准,可能反映了衰老过程.
- 注射吸毒者 (PWID) 是一个易受伤害的人群,艾滋病毒的流行率很高.
研究的目的:
- 评估艾滋病毒感染,疾病严重程度和表观遗传年龄之间的关系.
- 检查表观遗传衰老加速和艾滋病毒感染与死亡率的联合关联.
主要方法:
- 使用多个时钟 (PhenoAge,Horvath,Hannum,GrimAge,DunedinPACE) 来评估表观遗传年龄.
- 使用线性混合效应回归和考克斯模型来分析表观遗传年龄加速和死亡率.
- 分析了来自巴尔的摩PWIDALIVE研究队列的数据.
主要成果:
- 艾滋病毒感染者 (PWH) 比没有艾滋病毒感染者 (PWoH) 呈现出更大的表观遗传年龄加速.
- 艾滋病毒感染和表观遗传衰老加速独立地与增加全因死亡率有关.
- PhenoAge的加速与艾滋病毒感染或不感染的死亡风险显著增加有关.
结论:
- 艾滋病毒感染,不受控制的病毒血症和免疫恢复不良与表观遗传衰老加速有关.
- 表观遗传衰老加速有助于PWID的死亡风险.
- 准分子衰老过程可能会减轻PWH和PWID的死亡率.
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