一种致癌,截断的FGFR1变体与SPFQ/NONO合作,调节FGFR1驱动的白血病中的基因转录

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Updated: Mar 15, 2026

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John K Cowell1, Xuexiu Fang1, Stephanie F Mori1

  • 1Georgia Cancer Center, Augusta, Georgia, USA.

British journal of haematology
|March 14, 2026
PubMed
概括

一种截断的纤维细胞生长因子受体-1 (FGFR1) 衍生物通过与SFPQ和NONO蛋白形成复合体来驱动白血病. 针对这种复杂的NONO抑制剂,如奥拉诺芬,在治疗FGFR1驱动的白血病方面表现有前途.

关键词:
一个FGFR1.这就是NONO NONO.在SFPQQ中,SFPQ是最重要的.这种白血病是白血病.电阻的电阻是指电阻的电阻

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