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协调生态毒理学数据报告:毒理学家和化学家的指南

Surendra Balraadjsing1, Philipp Kropf1, Annetrude Boeije1

  • 1Institute of Environmental Sciences (CML), Leiden University, PO Box 9518, 2300 RA, Leiden, The Netherlands.

Environmental toxicology and chemistry
|March 14, 2026
PubMed
概括

生态毒理学的科学报告往往缺乏细节,阻碍了数据的重复使用和可重复性. 这项研究分析了关于纳米材料,子类药物和PFAS的已公布数据,以确定报告缺陷并提出解决方案.

关键词:
数据质量数据质量数据质量数据报告数据报告.统一化和化 统一化和化可复制性的可复制性标准化 标准化 标准化

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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