来自一项随机对照试验的患者报告结果,该试验比较了右侧单边电疗法与双极性抑郁症的基于算法的药理治疗,并对药理治疗进行了长期跟踪
Jeanette Bjørke1,2,3, Helle Schøyen1, Arne Vaaler4,5
1Division of Psychiatry and the Research Department, Stavanger University Hospital, Stavanger, Norway.
Bipolar disorders
|March 14, 2026
概括
右侧单侧电疗法 (RUL ECT) 显示出比基于算法的药理疗法 (APT) 对治疗耐药双极性抑郁症的急性益处更大,这是患者报告的结果和临床医生的评价所表明的. 长期结果在各组之间是相似的.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床医学 临床医学
背景情况:
- 抗治疗的双极性抑郁症是一个重大的临床挑战.
- 电疗法 (ECT) 和基于算法的药理疗法 (APT) 是已知的治疗方式.
- 对比患者报告结果 (PROM) 和临床医生评级对于评估治疗疗效至关重要.
研究的目的:
- 为了比较急性和长期PROM和治疗耐药双极性抑郁症患者的临床医生评估结果.
- 为了评估右侧单边 (RUL) ECT与APT在6周的治疗期和随后6个月的随访期间的疗效.
主要方法:
- 随机对照试验涉及住院患者治疗耐药双极性抑郁症.
- 干预包括6周的RUL ECT或APT,随后是6个月的维持药物治疗.
- 评估了PROMs (RAND-36,EMQ-28,PGI-I) 和临床医生评级的MADRS在基线,治疗后和6个月的随访期间.
主要成果:
- 与APT相比,在治疗后立即,RUL ECT在RAND-36维度和PGI-I方面表现出优异的改善.
- 临床医生评估的MADRS得分也显示,随着RUL ECT后期治疗,MADRS得分得到了更大的改善.
- 在6个月后,没有观察到任何显著的群体差异,尽管RUL ECT显示EMQ-28得分持续改善.
结论:
- 在治疗治疗耐药双极性抑郁症方面,RUL ECT比APT提供了明显的好处,得到了患者和临床医生的测量支持.
- 这些发现凸显了RUL ECT对这一患者群体的急性疗效.
- 在6个月后,两组治疗组之间的长期功能结果没有显著差异.
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