怀孕期间母亲的皮质醇水平:与胎儿人类学和产后三个月婴儿认知发育的关联
Bruna de Farias Sokolovsky1, Fernanda Teixeira Coelho2, Tatiane Bilhalva Fogaça1
1Postgraduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil.
Psychoneuroendocrinology
|March 14, 2026
概括
怀孕期间母亲的高皮质醇与更大的胎儿生长测量有关,但婴儿认知得分较低. 这表明皮质醇明显影响胎儿发育和早期神经发育.
科学领域:
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 怀孕涉及显著的内分泌变化,包括母体皮质醇升高,对胎儿成熟至关重要.
- 虽然是必不可少的,但过度的母性皮质醇可能会对胎儿生长和婴儿神经发育产生负面影响.
研究的目的:
- 为了研究孕期母亲血清皮质醇水平与胎儿人类测量水平之间的关联.
- 探索妊娠期皮质醇与婴儿在三个月大时的认知发育之间的关系.
主要方法:
- 这项研究包括来自巴西南部的632个母婴双,数据是在第二或第三季度收集的.
- 通过超声波评估胎儿人类学;测量母亲血清皮质醇.
- 婴儿的认知发展在三个月后使用贝利婴幼儿发展尺度,第三版 (Bayley-III) 进行评估.
主要成果:
- 较高的孕期皮质醇水平与胎儿头周,腹周,股骨长度和双直径的增加有关.
- 没有发现母亲的皮质醇和估计的胎儿体重之间存在显著的关联.
- 怀孕期间母亲皮质醇升高与婴儿认知分数在三个月大时降低相关.
结论:
- 孕期孕产妇皮质醇水平表现出双重效应,积极影响某些胎儿生长参数,同时与婴儿早期认知功能下降有关.
- 进一步研究皮质醇这些独特影响背后的生物机制是有必要的.
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