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通过Fe₃O₄@Cu_2-xS工程调节M1巨细胞极化,以改善瘤免疫疗法和MRI

Changzhou Shi¹, Yangang Zhu¹, Yanchen Wang¹

¹Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China; School of Medical Imaging, Xuzhou Medical University, Xuzhou 221004, China.

Colloids and surfaces. B, Biointerfaces

|March 14, 2026

概括

使用Fe3O4@Cu2-xS纳米材料改造的M1巨细胞重新编程M2巨细胞,通过促进抗瘤免疫反应和实现非侵入性监测来增强癌症免疫疗法. 这种方法可以提高治疗效率.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
免疫学免疫学免疫学

背景情况:

与瘤相关的巨细胞 (TAMs),特别是M2表型,阻碍了癌症免疫治疗的有效性.
将M2巨细胞重新编程为促炎M1表型对于有效的癌症治疗至关重要.

研究的目的:

开发核心外Fe3O4@Cu2-xS纳米材料,用于设计M1巨细胞 (Fe3O4@Cu2-xS@M1),以增强瘤免疫疗法.
研究Fe3O4@Cu2-xS@M1对M2巨细胞重编程和在瘤微环境 (TME) 中激活抗瘤免疫的能力.

主要方法:

核心外Fe3O4@Cu2-xS纳米材料的制造.
使用Fe3O4@Cu2-xS纳米材料 (Fe3O4@Cu2-xS@M1) 工程M1巨细胞.
评估巨细胞重编程,细胞因子释放 (NO,TNF-α),抗瘤免疫激活,瘤进展抑制,以及体内MRI跟踪.

主要成果:

Fe3O4@Cu2-xS@M1有效地定位到瘤部位,并在TME中维持了M1表型.
工程M1巨细胞诱导了邻近细胞的M2-to-M1表型转化,并通过多个通路调节延长了M1状态.
Fe3O4@Cu2-xS@M1表现出增强的抗瘤免疫力,抑制了瘤的进展,并促进了非侵入性的MRI可视化.

结论:

Fe3O4@Cu2-xS纳米材料可以设计巨细胞以改善癌症免疫疗法.
这种方法有效地重编程瘤微环境,增强抗瘤反应,并允许通过MRI进行监测.
具有内在免疫调节特性的纳米材料为有效的癌症治疗提供了一个有希望的战略.

关键词:

工程巨细胞的工程这就是为什么MRI是MRI.巨细胞的两极分化纳米颗粒是如何形成的瘤免疫疗法免疫疗法

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