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通过多任务深度学习对膝关节骨关节炎进行跨机构的五类凯尔格伦-劳伦斯分级
Tariq Alkhatatbeh1,2,3, Ahmad Alkhatatbeh4, Yan Liao1,2,3
1Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Guangzhou, China.
凯尔格伦-劳伦斯 (KL) 评分的深度学习模型显示出有希望的结果,但在概括方面存在困难. KL-FuseNet是一种新的架构,在对特定领域进行微调后,可以实现高精度,从而实现可靠的临床部署.
科学领域:
- 人工智能的人工智能
- 医疗成像医学成像
- 计算机视觉 计算机视觉
背景情况:
- 凯尔格伦-劳伦斯 (KL) 评分的深度学习模型通常由于数据泄露而表现乐观.
- 由于领域转移,这些模型经常无法在不同的机构中进行概括,从而造成可重现性危机.
研究的目的:
- 推出KL-FuseNet,这是一个多任务深度学习架构,旨在融合全球和本地特征,以改进KL分级.
- 为了应对数据泄露和自动化骨关节炎评估领域转移的挑战.
主要方法:
- 开发了KL-FuseNet,这是一个多任务架构,结合了ConvNeXt-Base和ResNet-50功能,用于预测顺序等级,标签分布和二进制严重性 (KL≥2).
- 在内部骨关节炎倡议数据集 (n=8260) 和独立的中国队列 (n=2295) 上使用了严格的患者智能分层划分.
- 将零射击转移性能与用于跨机构通用化的选择性微调协议进行比较.
主要成果:
- KL-FuseNet显示了强大的内部协议 (QWK:0.881,准确率:70.3%).
- 外部零射击部署显示了域间隙 (准确率:66.1%),但选择性微调显著改善了性能 (准确率:80.0%,QWK:0.950,KL≥2的AUC:0.984).
结论:
- 在严格的评估下,KL-FuseNet实现了最先进的性能,但对于临床实用性而言,域意识的适应是至关重要的.
- 这项研究建立了一种可重复的方法,用于在各种医疗中心部署自动分级模型,从而提高骨关节炎诊断.
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