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使用全身免疫炎症指数评估多肌痛性风湿性疾病活动:一项回顾性横截面研究

Sibel Ösken¹, Başak Bilir Kaya²

¹Department of Rheumatology, Istanbul Erenköy Physical Therapy and Rehabilitation Hospital, Merdivenköy, Ressam Salih Erimez Cad No:21, 34732, Kadıköy, Istanbul, Türkiye. sibeltos@yahoo.com.

Clinical rheumatology

|March 14, 2026

概括

系统性免疫炎症指数 (SII) 与多发性肌痛类风湿性疼痛 (PMR) 中的疾病活性相关. 较高的SII水平表明PMR疾病活性较高,为监测患者提供潜在的非侵入性标志物.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
生物标志物发现发现

背景情况:

多发性肌痛风湿症 (PMR) 是老年人常见的炎症状况,导致肩膀和骨盆腰带疼痛和硬.
目前的评估工具,如PMR活动评分 (PMR-AS) 存在,但可访问的炎症生物标志物对疾病活动是有限的.
系统性免疫-炎症指数 (SII),从常规血液计数计算出来,是系统性炎症的新标志物.

研究的目的:

评估系统性免疫-炎症指数 (SII) 和疾病活性之间的相关性,通过PMR活动得分 (PMR-AS) 测量,在患有多发性肌痛类风湿症 (PMR) 的患者中.

主要方法:

一项涉及180名PMR患者的回顾性横截面研究.
诊断时对临床和实验室数据的分析,包括用于SII计算和PMR-AS的完整血液样本.
皮尔森相关性和多变量线性回归来评估SII和PMR-AS之间的关联,基于疾病活性进行分层.

主要成果:

系统性免疫炎症指数 (SII) 在中度至高PMR疾病活性的患者中显著更高.
SII与PMR活动得分 (PMR-AS) (r=0.47) 显示了中度的正相关性.
在多变量分析中,SII和冠状动脉疾病 (CAD) 都被确定为中度至高疾病活动的独立预测因素.

结论:

系统性免疫-炎症指数 (SII) 似乎是一个有价值的,非侵入性指标,在多肌痛类风湿 (PMR) 的疾病活动.
较高的SII水平,以及CAD的存在,独立地与增加的PMR疾病活性有关,强调了全身炎症.
常规评估SII可能会加强PMR患者的疾病监测和临床评估.

关键词:

生物标记物生物标记物疾病活动疾病活动炎症炎症是一种炎症.多重肌痛类风湿症多重肌痛类风湿症系统性免疫炎症指数

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