在息治疗患者的 Delirium 严重程度轨迹和生存结果
Duan Guo1,2, Jinrong Hu1, Yaoli Wang1
1Department of Palliative Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan Province, China.
概括
在息治疗中,严重妄恶化的轨迹与明显更高的死亡风险有关. 识别这些模式可以改善患者的预后,并指导量身定制的管理策略.
科学领域:
- 抚慰性护理医学 抚慰性护理医学
- 老年精神病学是一门精神病学专业.
- 在瘤学瘤学.
背景情况:
- 痴呆症严重程度的轨迹与预后不佳有关,但在息治疗方面的证据有限.
- 没有先前的研究专门研究了妄的轨迹和息护理患者的生存结果.
研究的目的:
- 在息治疗患者中识别出明显的 Delirium 严重性轨迹.
- 探索这些轨迹与生存结果之间的关联.
主要方法:
- 一个纵向前性队列研究在息治疗单位进行.
- 213名患有痴呆症的晚期癌症患者每周两次使用纪念痴呆症评估量表 (MDAS) 进行评估.
- 使用基于组的轨迹建模和Cox比例危险回归来分析数据.
主要成果:
- 确定了三种 Delirium 严重性轨迹:轻微恶化,严重恶化和严重缓解.
- 严重恶化组在对共变量进行调整后,与严重缓解组相比,死亡风险显著增加 (HR 3.006).
- 轻度恶化组与严重缓解组相比,死亡风险在统计学上没有显著差异.
结论:
- 在息治疗患者中,存在三种不同的 Delirium 严重性轨迹.
- 严重恶化的轨迹与预后最差和死亡率增加有关.
- 这些发现支持预后评估和息治疗中的个性化妄管理.
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