在为精神病治疗的人群中,开发一个多基因风险评分来衡量体重增加 - - 在现实世界中应用
Adrian Heald1,2, Yasitha Illangasekera3,4, Camila Marcelino Loureiro3
1Department of Endocrinology and Diabetes, Salford Royal Hospital, Salford, UK.
Human psychopharmacology
|March 14, 2026
概括
一个新的多基因风险评分 (PRS) 能够有效预测抗精神病药物诱导的体重增加 (AIWG) 在患有第一发精神病的女性中. 这种遗传倾向工具解释了59%的每日体重增加随时间变异.
科学领域:
- 药物遗传学 药物遗传学
- 精神病学是一个精神病学.
- 基因组学就是基因组学.
背景情况:
- 遗传因素显著影响抗精神病药物诱导的体重增加 (AIWG).
- 多基因风险评分 (PRS) 提供了一种方法来量化对AIWG的遗传倾向.
- 了解AIWG遗传基础对于个性化治疗第一发精神病至关重要.
研究的目的:
- 开发和验证一种PRS,用于预测AIWG在患有第一发精神病的个体.
- 调查新型PRS与体重随时间变化之间的关联.
- 探索PRS对AIWG的预测能力中的潜在性别差异.
主要方法:
- 通过使用与AIWG相关的六个基因 (HTR2C,MTHFR,ADRA2A,MC4R,LEPR,CNR1) 的单核酸多态 (SNPs) 构建了一个PRS.
- 创建了附加和加权的PRS模型,以及低/高遗传风险组.
- 回归分析检查了PRS与每天体重增加 (WGPD) 和BMI百分比变化之间的关联.
主要成果:
- 添加剂PRS在女性中显著预测了AIWG (r2 = 0.59,p < 0.05),但在男性中没有.
- 高遗传风险群体表现出更大的WGPD (p = 0.018),具有显著的PRS-性别相互作用.
- 在PRS模型和BMI百分比变化之间没有发现显著的关联.
结论:
- 结合特定SNP的PRS可以预测患有第一发精神病的女性的每日体重增加,这解释了差异的很大一部分.
- 需要在独立队列中进一步验证.
- 在AIWG管理中,PRS的未来应用可行性需要进一步调查.
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