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Updated: Mar 16, 2026

Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems
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Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems

Published on: October 14, 2025

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通过TIGR-TasH系统对双间距导向目标切割的分子基础

Jie Yang1, Tongyao Wang1, Zhikun Liu1

  • 1Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, Tianjin's Clinical Research Center for Cancer, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular Homeostasis and Disease, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin 300070, China.

Molecular cell
|March 14, 2026
PubMed
概括

这项研究揭示了TIGR-TasH复合体如何使用双导向RNA来准DNA. 研究人员通过了解关键蛋白质结构的腺因特异稳定,设计了一种新的尼克酶.

关键词:
虎-塔什 (TIGR-TasH) 是一个巨大的虎.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.基因组编辑 基因组编辑导向RNA定义的尼克酶.多重基因组编辑多重基因组编辑虎RNA成熟的过程

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