在PCV13被PCV10替换后,肺炎球菌血清型流行病学和耐药性,瑞典,瑞典
Linda Yamba Yamba1, Fabian Uddén2, Silvana Dalence3
1Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Inga Marie Nilssons gata 53, Wallenberg laboratoriet, SE21428 Malmö, Sweden; Clinical Microbiology, Infection Control and Prevention, Laboratory Medicine Skåne, Sölvegatan 23B, SE22185 Lund, Sweden.
The Journal of infection
|March 14, 2026
概括
瑞典 瑞典 瑞典 瑞典
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 瑞典在2018年在其儿童免疫计划中从PCV13过渡到PCV10.
- 这次转换旨在重新评估对Streptococcus pneumoniae血清型分布的影响.
研究的目的:
- 评估PCV13转为PCV10疫苗对瑞典肺炎球菌血清型分布的影响.
- 为了监测血清型流行率和抗菌素耐药性模式的变化,疫苗后的政策变化.
主要方法:
- 对1,615个呼吸道 (RT) 菌株 (Streptococcus pneumoniae) 隔离物 (2020-2023) 进行血清定型和抗菌素敏感性的分析.
- 与397个侵入性肺炎球菌病 (IPD) 隔离物和PCV13时代 (2016-2018) 的历史数据进行比较.
主要成果:
- 血清型3和19A在PCV10重新引入后在RT分离物中重新出现,占主导地位 (p<0.001).
- 血清型19A在IPD病例中也显著增加 (p<0.001).
- 在11%的RT分离物体中发现了减少的zylpenicillin敏感性,多药耐药性主要存在于15A和19A血清型中.
结论:
- 重新引入PCV10导致3和19A血清型的复苏.
- 持续监测至关重要,突出显示了快速用低价值疫苗替代血清型的风险.
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