用远程多日尿路诊断为男性LUTs的实用表型框架
Jeremy Watts1, Daniel Godelfer1, John Knoedler1
1iO Urology Corporation, Knoxville, TN, USA.
Urology
|March 14, 2026
概括
远程多日尿路诊断 (RMUD) 显示男性下尿路症状 (LUTS) 的不同模式. 这种表型识别识别了混合阻塞,过度活跃和夜间多尿症表型,有助于个性化治疗.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医学诊断 医学诊断 医学诊断
- 患者的表型定型
背景情况:
- 下尿道症状 (LUTS) 影响了许多男性.
- 准确的表型定型对于有效的LUTS管理至关重要.
- 当前的诊断方法可能无法完全捕捉症状的复杂性.
研究的目的:
- 用远程多日尿道诊断 (RMUD) 描述LUTS男性的索引症状和诊断概况的分布.
- 建立基于RMUD数据的LUTS的表型框架.
主要方法:
- 对1047个RMUD研究的回顾性分析,这些研究涉及患有LUTS的男性.
- RMUD结合了频率-体积,尿道流量计和国际前列腺症状评分 (IPSS) 数据.
- 定义了六个指数症状和非重叠的诊断概况.
主要成果:
- 37.6%的男性符合阻塞性标准; 33.5%的男性过度活跃,其中13.9%的男性主要过度活跃.
- 夜尿 (>2/夜) 影响67.3%,夜间多尿 (NP) 影响46.8%.
- 21个不同的诊断档案出现,经常显示混合的存储-空白-NP表型.
结论:
- 基于RMUD的表型化揭示了男性中LUTS呈现的显著异质性.
- 确定的模式包括阻塞,过度活跃和夜间多尿症.
- 该框架支持精确的患者咨询,治疗选择和进一步评估.
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