在患有肺动脉高血压的患者的风险分层中,右心房相位应变
Jiajun Guo1, Shuang Leng2, Juan He1
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
概括
右心房储压力是肺动脉高血压 (PAH) 患者死亡率的强有力的预测因素. 这一指标有效地将PAH患者分为风险组,提高预后准确性.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 肺高血压是什么意思 肺高血压
背景情况:
- 在肺动脉高血压 (PAH) 中,右心房 (RA) 阶段功能受损.
- 关于RA菌株在PAH患者风险分层中的临床意义的证据有限.
- 这项研究旨在评估RA储菌株,以评估PAH的预后.
研究的目的:
- 在肺动脉高血压 (PAH) 患者中评估右心房 (RA) 储应变的预后值.
- 为了确定RA储菌株是否可以有效地将PAH患者分为不同的风险类别.
- 为了将RA储菌株的预后性能与其他心脏磁共振 (CMR) 衍生的指标和现有的风险模型进行比较.
主要方法:
- 预计从2013年6月到2022年12月招募348名PAH患者.
- 使用C指数,1年死亡率和年度事件率评估预后表现.
- 根据1年死亡率分为低风险,中风险和高风险群体的分层.
主要成果:
- 独立地预测了所有原因的死亡率 (HR = 0.950,P < 0.001).
- 患者被分为风险组,一年死亡率为24.0% (高),5.5% (中等) 和0.0% (低).
- 与其他CMR指标相比,RA储菌株表现出优异的区分能力 (C指数:0.79),并改进了REVEAL Lite 2模型.
结论:
- 与PAH中的RV功能参数相比,RA储菌株是死亡率的优越预测因素.
- 实际上,RA储菌株有效地将PAH患者分为低风险,中等风险和高风险组.
- RA 储菌株有可能成为PAH患者多参数评估的关键组成部分.
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