优化无氧消化以降低抗生素降解和减轻抗菌素耐药性
Jing Xie1, Wenzhe Zhu1, Wen Wang2
1Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
Bioresource technology
|March 14, 2026
概括
优化无氧消化 (AD) 用富含葡萄糖的原料在介质温度提高林氏素降解和甲回收,同时减少抗生素耐药性基因的传播. 富含蛋白质的热友环境增加了耐药性风险.
科学领域:
- 环境微生物学 环境微生物学
- 生物技术是生物技术.
- 废水处理 废水处理
背景情况:
- 无氧消化 (AD) 对于处理制药废水,减轻抗菌素耐药性 (AMR) 和恢复生物能量至关重要.
- 运营策略显著影响AD效率和AMR风险控制.
- 林氏素降解和AMR传播是抗生素加载废水处理中的关键问题.
研究的目的:
- 系统地评估原料组成和消化温度对林氏素降解和AMR传播在AD期间的影响.
- 确定林氏素去除和甲生产的最佳条件.
- 了解在不同操作参数下驱动AMR扩散和水平基因转移 (HGT) 的机制.
主要方法:
- 在中性和热性条件下对富含葡萄糖的原料与富含蛋白质的原料进行比较分析.
- 评估林氏素降解效率和甲回收率.
- 基因组组装基因组 (MAG) 分析,以调查微生物社区结构,功能和AMR基因丰富度.
- 分析加工产品和潜在的HGT机制.
主要成果:
- 富含葡萄糖的美索菲尔消化在林氏素降解和甲回收方面显著优于热友和富含蛋白质的系统.
- 富含葡萄糖的条件促进了关键降解细菌 (例如,Clostridium,Methanobacterium) 的生长,并降低了ARG-MGE并发症和HGT潜力.
- 富含蛋白质和热友性的操作导致ARG的丰富性增加,这是由耐药联合体的扩散和通过移动遗传元素 (MGE) 增强的HGT所驱动的.
- 原材料的成分对抗药性耐药性传播的影响比温度更为明显.
结论:
- 富含葡萄糖的中性无氧消化为含有林氏素的废水处理提供了卓越的操作策略,平衡了有效的污染物清除与最小化的AMR风险.
- 了解微生物社区动态和HGT对于设计有效的废水处理过程至关重要.
- 这项研究为抗生素污染废水的可持续管理和利用提供了一个框架.
相关概念视频
01:18Amino Acid Catabolism
1.5K
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
1.5K
01:30Environmental Applications of Microorganisms
1.4K
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
1.4K
01:28Biological Methods for Microbial Control
1.2K
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
1.2K
01:28Antimicrobial Effectiveness
1.7K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.7K
00:57Antibiotic Selection
61.9K
Overview
61.9K
01:30Development of Antibiotic Resistance
1.8K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.8K