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Updated: Mar 16, 2026

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在LUAD中,IGF2BP3-TRIM37-P53轴促进瘤进展

Ting Ji1, Tingting Zhao1, Shuni Wang2

  • 1Ningxia Key Laboratory of Clinical and Pathogenic Microorganisms, Institute of Medical Science, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China; Department of Respiratory and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China.

Cellular signalling
|March 14, 2026
PubMed
概括

胰岛素样生长因子2 mRNA结合蛋白3 (IGF2BP3) 通过稳定TRIM37 mRNA促进肺腺癌 (LUAD),导致p53蛋白降解. 沉默TRIM37可以抑制LUAD的进展,提供治疗点.

关键词:
在 IGF2BP3BP3 中.卢阿德 (Luad) 的意思是说.在 TRIM3737 中,m6A 修改的修改在 p53 里,p53 是一个 p53 的类型.

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