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一个来自Bupleurum chinense DC的阿拉伯银河系. 减轻RAW264.7巨细胞中LPS诱导的炎症

Bowen Zheng¹, Chenxu Jiang², Zheng Wang³

¹School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong, China; Food Resources Development and Health Product Creation International Joint Laboratory/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology (Shandong Academy of Sciences), Heze, 274000, China; Institute of Traditional Chinese Medicine, Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.

Carbohydrate polymers

|March 14, 2026

概括

这项研究确定了一种来自Bupleurum的天然阿拉比诺格拉克坦 (BCP-WB),具有显著的抗炎性质. 通过与TLR4相互作用,BCP-WB抑制炎症通路,为天然抗炎疗法提供了潜力.

科学领域:

自然产品化学自然产品化学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

炎症对防御至关重要,但慢性炎症会导致疾病.
自然化合物,特别是多糖,正在研究其抗炎作用.
布普勒鲁姆是一种药用植物,具有潜在的治疗化合物.

研究的目的:

来自Bupleurum chinense的阿拉比诺银河体 (BCP-WB) 的结构的特征.
评估BCP-WB的抗炎作用.
阐明BCP-WB抗炎作用背后的分子机制.

主要方法:

使用物理化学方法对BCP-WB的结构性表征.
在LPS诱导的RAW264.7细胞和斑马鱼模型中评估抗炎活性.
用于转录分析的RNA测序和用于目标验证的分子对接/SPR.

主要成果:

BCP-WB是一种阿拉比诺银河体,分子量为34.4kDa.
BCP-WB显著降低了诸如中性粒细胞分散,NO和细胞因子产生等炎症标志物.
BCP-WB直接与TLR4结合,抑制NF-κB和MAPK信号通路.

结论:

BCP-WB具有强大的抗炎作用.
抗炎机制涉及TLR4结合和随后的关键信号通路的抑制.
来自Bupleurum chinense的BCP-WB是开发天然抗炎剂的有希望的候选人.

关键词:

抗炎症机制抗炎症机制布普勒鲁姆中国人DC.中性多糖化物中性多糖化物结构性表征结构性表征

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