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优化全球基因组监测,以便早期检测新出现的SARS-CoV-2变种

Haogao Gu¹, Jifan Li², Wanying Sun³

¹School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. guhaogao@hku.hk.

Nature communications

|March 15, 2026

概括

在主要枢纽对国际旅行者进行有针对性的基因组监测可以改善早期检测新型病毒变种. 该战略增强了全球公共卫生准备,同时优化了监测资源.

科学领域:

流行病学流行病学
基因组监测基因组监测
数学建模的数学建模

背景情况:

全球病毒传播需要有效的基因组监测来检测变种和公共卫生反应.
高成本和有限的测序能力阻碍了公平的全球监测实施.
旅行者在枢纽的监控是一个拟议的补充策略,但它的好处需要量化.

研究的目的:

量化国际枢纽加强旅行者监控的好处,以检测新的病毒变种.
评估有针对性的监控策略在补充当地努力方面的有效性.
为改善全球基因组监测和流行病准备提供一个框架.

主要方法:

为SARS-CoV-2传播开发和校准一个多株转型人口模型.
综合流行病学,遗传学和高分辨率的航空旅行数据.
对Omicron变种出现的回顾性分析和对假设变种的前模拟.

主要成果:

在关键枢纽进行有针对性的旅行者监控,大大缩短了变种检测延迟的时间.
优化策略,专注于高度连接的枢纽,减少整体监控工作.
在各种变体传播和疫苗有效性的不同场景中保持有效性.

结论:

在主要枢纽加强旅行者监测是补充当地基因组监测的有效策略.
有针对性的,非破坏性的监测方法可以改善全球对未来流行病的准备.
这种定量框架支持加强全球基因组监测系统.

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