相关实验视频
Updated: Mar 16, 2026

12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
21.4K
在健康和疾病方面的FGF家族
Xiaoyu Liu1,2,3, Meiling Jing1,2,3, Yueyi Yang1,2,3
1Department of Endodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Molecular biomedicine
|March 15, 2026
概括
纤维细胞生长因子 (FGFs) 对发育和新陈代谢至关重要. 本综述整合了FGF信号通路,突出了它们在组织再生和阻断癌症生长中的双重作用,以促进治疗创新.
科学领域:
- 分子生物学分子生物学
- 细胞信号传递 细胞信号传递
- 内分泌学 在内分泌学.
背景情况:
- 纤维细胞生长因子 (FGFs) 和它们的受体 (FGFRs) 调节胚胎模式,组织再生和代谢平衡.
- 规范性FGFs控制局部组织动态,而内分泌FGFs (FGF19,FGF21,FGF23) 作为胆酸,葡萄糖和代谢的全身激素.
- 现有的FGF途径知识缺乏整合结构多样性,监管和健康和疾病中的角色的统一框架.
研究的目的:
- 系统地审查FGF家族的分类,结构和受体特异性,包括正规,内分泌和细胞内FGF.
- 划分正规和非正规的FGF信号通路及其涉及硫酸蛋白质糖,Klotho核受体和反环的调节机制.
- 整合当前关于FGF在器官发育,组织修复,新陈代谢调节和疾病发病过程中的作用的见解,强调治疗潜力.
主要方法:
- 系统审查关于FGF信号的科学文献.
- 分析FGF的结构多样性,受体相互作用和辅因子作用.
- 整合关于FGF功能在发育,新陈代谢和疾病中的数据.
主要成果:
- FGF表现出多样化的结构和信号机制,包括规范性,非规范性和细胞内通路.
- 调控涉及硫酸蛋白糖,克洛托核受体和细胞内反,使细胞命运和器官间通信能够精确控制.
- FGF信号传递在胚胎发育,组织修复,代谢平衡和各种疾病的发病过程中起着至关重要的作用.
结论:
- 针对FGF轴提供治疗双重性:对再生和代谢障碍的对抗性,对癌症治疗的对抗性.
- 对FGF信号的综合理解对于开发新型治疗策略至关重要.
- 本次审查为未来的基于FGF的治疗方法的研究和创新提供了基础框架.
相关概念视频
Transducer Mechanism: G Protein–Coupled Receptors
6.8K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
GPCRs are also called heptahelical,...
6.8K
Pharmacogenomics: Identification of New Drug Targets
73
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
73
Cystic Fibrosis: Pathogenesis
1000
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1000
Factors Affecting Illness
5.6K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
5.6K
Activation and Inactivation of G Proteins
12.1K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
12.1K
Genome-wide Association Studies-GWAS
16.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.5K

