患有牛皮关节炎的患者间歇性肺病的患病率:系统性审查和元分析
Pannathorn Nakaphan1, Varote Shotelersuk2, Patavee Pajareya3
1Department of Internal Medicine, University of Missouri-Kansas City, Kansas City, MO, USA. pannathorn0769@gmail.com.
间歇性肺病 (ILD) 影响了3%的牛皮关节炎 (PsA) 患者,通过成像检测出更高的患病率. 吸烟增加了PsA的ILD风险,突出了更好的识别和查的需要.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 牛皮关节炎 (PsA) 通常与间歇性肺病 (ILD) 不相关.
- 新出现的证据表明,肺部参与PSA的患病率比以前理解的要高.
- 在PsA患者中ILD的确切患病率尚不清楚.
研究的目的:
- 为了确定在患有PsA的患者中ILD的综合流行率.
- 为了确定与PSA中ILD相关的风险因素.
- 将PsA患者的ILD风险与其他人群进行比较.
主要方法:
- 进行了系统性审查和元分析.
- 数据来源于MEDLINE,EMBASE和科克兰图书馆,截至2026年1月.
- 使用随机效应模型,从6项涉及14272名PsA患者的观察性研究中汇集了患病率估计.
主要成果:
- 在PsA中ILD的整体综合患病率为3% (95%CI:1-7%).
- 在使用成像 (CT/HRCT) 与非成像方法 (1%) 的研究中,患病率显著更高 (6%) (p < 0.0001).
- 吸烟是PsA中ILD的一个显著风险因素 (OR2.94,95%CI:1.22-7.12).
结论:
- 在PsA中,ILD是一种相关的并发症,影响了相当一部分患者.
- 基于成像的诊断方法显示,在PsA中ILD的患病率更高.
- 提高临床意识,标准化诊断和进一步的研究对于管理PsAILD至关重要.
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