人类足部皮肤的生物力学:实验和构成性分析
Chiara Giulia Fontanella1,2, Sofia Pettenuzzo3, Alice Berardo1,2
1Department of Industrial Engineering, University of Padova, Padua, Italy.
Annals of biomedical engineering
|March 15, 2026
概括
这项研究描述了人类足部皮肤的机械性质,揭示了其异构和时间依赖的行为. 这些发现为了解脚皮肤机制和开发治疗糖尿病脚等疾病提供了有价值的模型.
科学领域:
- 生物力学 生物力学
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 脚底皮肤对于脚的保护和应激适应至关重要.
- 糖尿病足部是具有挑战性和昂贵的伤口.
- 关于脚皮的机械特性和与疾病相关的变化,研究有限.
研究的目的:
- 为了全面描述人类足部皮肤的机械行为.
- 分析机械性能如何在不同脚部区域和方向上变化.
- 为脚部皮肤力学开发一个构成模型.
主要方法:
- 在人类足部皮肤样本上进行了拉伸,压缩和应力放松测试.
- 测试的样本在后部-前部 (PA),侧部-中部 (LM) 和头骨-尾部 (CC) 方向.
- 使用反向分析来参数化一个异型粘性-超弹性构成模型.
主要成果:
- 脚部皮肤表现出非线性,异型和时间依赖的机械行为.
- 在前足和后足区域之间观察到显著的差异.
- 在这两个区域,PA方向的弹性模量高于LM方向.
- 压缩弹性模块在后部区域的延展率随着延展率的增加而增加.
结论:
- 开发的构成模型准确地捕捉了脚部皮肤的机械反应.
- 该模型提供了对脚皮肤机制的洞察,有助于诊断疾病.
- 这项研究支持开发新的皮肤替代品和治疗策略.
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