在不同功能状态下,C-反应蛋白-三甘油-葡萄糖指数与中风风险之间的关联:一项国家队列研究

Wei Xian¹, Tong Wu², Xin-Xin Zhao^3,4

¹Department of Information Center, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshan dong Street, Shenyang, 110032, Liaoning, China.

Cardiovascular diabetology

|March 15, 2026

概括

反应性C蛋白-三甘油-葡萄糖指数 (CTI) 与中国老年人中风风险较高有关. 这种关联在患有轻度功能障碍的人群中尤为强烈,这表明CTI.

科学领域:

心血管流行病学心血管流行病学
代谢综合征研究研究
功能研究研究功能研究.

背景情况:

反应性C蛋白-三甘油-葡萄糖指数 (CTI) 结合了炎症和胰岛素耐药性标志物.
以前的研究表明,CTI和心血管疾病之间存在联系.
关于CTI和中风风险之间的关联,特别是关于功能,尚不清楚.

研究的目的:

调查CTI与发生中风风险之间的关联.
检查这种关联是如何被不同水平的估计膜过率 (eGFR) 改变的.

主要方法:

一项针对8808名年龄≥45岁的中国成年人进行的前性队列研究 (查尔斯,2011-2018).
使用C反应蛋白,甘油三和禁食血葡萄糖计算的CTI.
用于分析中风风险的多变量考克斯模型和受限立方线.
分层分析和相互作用术语评估了eGFR水平的影响.

主要成果:

在平均7年的随访期间,发生了404次中风事件.
一个单位的CTI增加与15%的中风风险增加有关 (HR=1.15).
观察到CTI和eGFR之间的显著相互作用 (P=0.037).
这种关联在轻度功能障碍 (eGFR 60-89 mL/min/1.73 m2) 患者中最强,最高CTI四分位数显示2.73倍的风险增加 (HR=2.73).

结论:

升高的CTI是中年和老年中国成年人中风的独立风险因素.
在患有轻度功能障碍的人群中,风险显著增加.
CTI可以作为评估中风风险的有价值的临床工具,特别是在功能不同的人群中.

关键词:

在CTI中,CTI是CTI.功能功能功能一次性中风,中风.在 TyG 里面,你会看到 TyG.

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