在患有性结肠炎的儿科患者中组织可能由infliximab引起的肺炎
Brian Lee1, Isaac Martin2, Kevin Bax3
1Department of Medicine, Division of Clinical Immunology and Allergy, Western University, London, Canada.
概括
本案例研究报告了一例罕见的组织性肺炎 (OP) 病例,该病例发生在为性结肠炎治疗infliximab的儿科患者身上. 停止使用生物药物导致症状在不使用皮质类固醇的情况下得到改善,这表明infliximab是潜在的原因.
科学领域:
- 肺部病理学 肺部病理学
- 儿科胃肠病学 儿科胃肠病学
- 类风湿病学 类风湿病学
背景情况:
- 组织性肺炎 (OP) 是一种罕见的间歇性肺病.
- 虽然OP往往是异常的,但可能是感染,自身免疫性疾病或药物使用的次要原因.
- 来自瘤亡因子-α (TNF-α) 抑制剂的肺部并发症不常见,之前没有报告过因弗利西马布相关的OP的儿科病例.
研究的目的:
- 报告儿科患者可能患有因弗利克西马布相关的组织性肺炎的病例.
- 提高人们对与生物疗法相关的罕见肺毒性的认识.
- 为了调查停止违规代理在管理这种情况的有效性.
主要方法:
- 一个12岁女孩患有性结肠炎 (UC) 的病例介绍. 在infliximab治疗中.
- 患者出现呼吸不全,发烧和胸痛,CT扫描显示双边外围透.
- 通过形活检确认了OP的诊断,并停止了因弗利西马布的治疗.
主要成果:
- 患者经历了症状改善和近乎完全的放射性解像度在因弗力西马布撤销后的两个月内.
- 康复不需要用皮质类固醇治疗.
- 微生物学测试和支气管支气管洗结果是负的.
结论:
- 这一案例表明,Infliximab的使用与儿童患者的肺炎之间存在可能的联系.
- 它强调了考虑生物药物的罕见肺部副作用的重要性.
- 在药物诱导的OP的特定情况下,停止致病生物制剂可能是足够的治疗策略.
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