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Updated: Mar 16, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Published on: February 3, 2022

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在p53中的proline丰富域的 conformational灵活性和短暂结构

Agnes Berggren1, Michael Bakker2, Hayden Fisher3

  • 1Division of Computational Chemistry, Department of Chemistry, Lund University, P.O. Box 124, 22100 Lund, Sweden; NanoLund, Lund University, P.O. Box 118, 22100 Lund, Sweden.

Biophysical journal
|March 15, 2026
PubMed
概括

瘤抑制剂p53的proline丰富域 (PRD) 在很大程度上是无序的,但具有短暂的结构. 氨酸残留物产生刚性,影响p53.

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