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天然产品作为抗衰老相关的分泌表型 (SASP) 剂
Lina Yang1, Yuan Liu2, Yuqing Li1
1Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China.
Current medicinal chemistry
|March 15, 2026
概括
自然化合物可以抑制衰老相关分泌表现型 (SASP),这是衰老和疾病的关键因素. 本综述探讨了这些天然产品如何针对SASP在与年龄相关的疾病中的潜在治疗益处.
科学领域:
- 老年学和细胞生物学,专注于衰老机制和干预措施.
背景情况:
- 细胞衰老,以衰老相关的分泌表现型 (SASP) 为特征,是生物体衰老和与年龄有关的疾病的关键驱动因素.
- SASP涉及老化细胞分泌各种生物活性分子,影响细胞外功能和病理过程.
- 针对SASP的老年形策略为缓解与年龄有关的病理提供了有前途的治疗潜力.
研究的目的:
- 系统地审查针对SASP的天然化合物.
- 分析这些天然化合物的机制,治疗潜力和临床翻译前景,用于治疗与年龄相关的非癌症疾病.
主要方法:
- 综合的文献搜索和关于自然化合物调节SASP的当前调查的整合.
- 对SASP的发起,组成和病理生理学作用的分析.
- 描述自然化合物如何与SASP相互作用和调节.
主要成果:
- 自然产品,包括多,黄和类,表现出抗氧化和抗炎性质.
- 这些天然化合物在老化和疾病模型中证明了对调节SASP的有效性.
- 该综述提供了对SASP调制中的自然化合物机制的基本理解.
结论:
- 自然化合物代表了针对SASP在与年龄相关的疾病中的有希望的治疗途径.
- 对其机制和临床转化进行进一步的研究是老化干预的必要条件.
- 本次审查为未来开发来自自然产品的老形疗法奠定了基础.
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