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基于氨基酸的配方奶粉和重复不耐受的早产婴儿的食结果:一个倾向性得分匹配的研究
Emine Ergül Sarı1, Çağrı Cumhur Gök1, Emrah Can2
1Department of Pediatrics, Bakırköy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Türkiye.
过渡的早产婴儿有食不耐受,以氨基酸为基础的配方 (AAF) 改善了食结果. 这种方法导致更早的全肠道养和更短的亲肠道营养 (PN) 持续时间.
科学领域:
- 新生儿科学 新生儿科学
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
背景情况:
- 复发性食不耐受 (FI) 是早产婴儿的一个重大挑战.
- 标准的早产配方可能无法充分解决这一群体中复杂的养问题.
研究的目的:
- 调查从标准早产婴儿配方切换到基于氨基酸的配方 (AAF) 的疗效,用于出现反复食不耐受的早产婴儿.
- 评估AAF对关键养结果和临床参数的影响.
主要方法:
- 一个回顾性队列研究比较了早产婴儿 (妊娠≤34周) 与复发性FI,这些婴儿过渡到AAF,与那些继续标准配方婴儿相比.
- 倾向性得分匹配用于控制群体之间的基线差异.
- 主要结局包括完整的肠道养时间和亲肠道营养 (PN) 持续时间;次要结局评估了FI复发,死角性肠球炎 (NEC),败血症和炎症标志物.
主要成果:
- 过渡到AAF的婴儿实现了更快的全肠养 (10 vs. 13天),并且需要更少的PN (9 vs. 12天).
- 在AAF组中,复发性FI的发生率明显低于AAF组 (15%对39%).
- 在怀疑NEC,败血症或36周月经后体重方面没有观察到显著差异;在没有临床过敏的AAF组中,乙素含量更高.
结论:
- 过渡到基于氨基酸的配方 (AAF) 是有益的早产婴儿与反复的食不耐受.
- AAF有助于更早地实现完全的肠道养,并减少对肠道营养的需求.
- 这种饮食改变似乎是安全的,没有增加感染或主要胃肠道并发症的风险.
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