胰腺切除术在儿科高胰岛素症中的结果:回顾单中心经验
Seyithan Ozaydin1, Nihal Coskun2, Ipek Yildiz Ozaydin3
1Department of Pediatric Surgery, Istinye University, Liv Hospital Bahcesehir, Istanbul, Turkey.
The Journal of surgical research
|March 15, 2026
概括
针对高胰岛素症 (HI) 的手术对对氧化不反应的病例至关重要. 胰腺切除术提供了必要的治疗方法,但对糖尿病和低血糖的长期监测对于婴儿的结果至关重要.
科学领域:
- 儿科手术 儿科手术
- 内分泌学 在内分泌学.
- 医学遗传学 医学遗传学
背景情况:
- 超胰岛素 (HI) 是导致婴儿持续低血糖的主要原因,可能导致神经损伤.
- 氧化物和氧化物等医疗治疗并不总是有效的,尤其是严重的KATP通道突变.
- 对于那些对医疗管理没有反应的患者来说,手术通常是必要的.
研究的目的:
- 为了评估我们机构中高胰岛素症患者的手术结果.
- 将这些结果与有关手术治疗HI的现有文献进行比较.
- 强调在管理HI时采用多学科方法的重要性.
主要方法:
- 针对HI进行胰腺切除术的14名患者的回顾性审查 (2008-2023年).
- 收集的数据包括人口统计,遗传发现,成像,手术细节,并发症和长期随访.
- 基于疾病表现 (扩散与焦点) 的手术方法 (近总和次总胰腺切除术) 的分析.
主要成果:
- 50%的患者患有ABCC8或KCNJ11突变; 78.6%患有先天性HI.
- 功能成像在3名非先天性HI患者中发现了焦点疾病.
- 在10年的随访中,38.4%患有糖尿病,30.8%患有复发性低血糖症,30.8%仍然患有高血糖症,30.8%患有神经发育迟缓.
结论:
- 胰腺切除术 (近全和亚全) 是耐胰岛素过高症的关键治疗方法.
- 早期遗传检测,先进的成像和全面的长期护理对于最佳的患者结果至关重要.
- 手术结果与国际研究结果一致,加强了它在治疗严重HI的作用.
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