香种子乙醇提取物 (Coriandrum sativum L.) 在高脂肪饮食诱导的老鼠中保护肝脏组织免受氧化应激和细胞衰老的影响
Novi Silvia Hardiany1, Syarifah Dewi1, Filda Vionita Irene de Lima2
1Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Current topics in medicinal chemistry
|March 15, 2026
概括
菜种子提取物减少了肥胖大鼠的肝脏氧化压力和细胞衰老. 这表明肥胖症对肝损伤有保护作用,需要进一步的安全性研究.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖会增加氧化压力,加速细胞衰老和肝脏损伤.
- 菜 (Coriandrum sativum L.) 的种子具有抗氧化特性.
- 在老鼠中,饮食引起的肥胖是研究代谢功能障碍的一个模型.
研究的目的:
- 为了研究大黄种子提取物对肥胖大鼠肝脏氧化应激和细胞衰老的影响.
- 评估大在肥胖中的潜在肝脏保护作用.
主要方法:
- 肥胖的老鼠被用大黄种子乙醇提取物 (100毫克/公斤) 治疗.
- 评估的体重,李指数,BMI和血脂质.
- 分析了肝脏组织的马隆迪甲 (MDA),催化酶活性,SA-β-Gal和p16INK4A表达.
- 评估肝脏组织学和功能标志物 (ALT,AST).
主要成果:
- 菜提取物降低了血甘油三,肝脏MDA,并增加了催化酶活性.
- 肝细胞衰老标志物 (p16INK4A) 减少;SA-β-Gal没有受到影响.
- 改善了肝脏组织学,降低了NASH得分和较低的ALT/AST水平.
结论:
- 菜种子提取物减轻肥胖大鼠的肝氧化压力和细胞衰老.
- 提取物在饮食引起的肥胖症中表现出肝脏保护作用.
- 需要进一步的临床前毒性研究来确认临床使用的安全性.
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