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在心力衰竭中,PGC-1α会加剧亡,从而诱导HIF-1α/BNIP3介导的线粒

Chengyao Ni1, Peng Hu1, Yiming Ni1

  • 1Department of Cardiothoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Biochemical and biophysical research communications
|March 15, 2026
PubMed
概括

过氧体增殖器激活受体 γ 协同激活剂 1 α (PGC-1α) 通过 HIF-1/BNIP3 途径增加细胞亡和线粒死,使心力衰竭 (HF) 恶化. 抑制这些过程可以减轻HF损伤.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.在BNIP3中,BNIP3是BNP3.这就是HIF-1α.心脏衰竭是因为心脏衰竭.线粒细胞衰变 - - 线粒细胞衰变 (mitophagy) 是一种它们是PGC-1α.

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