天然阿斯塔克桑通过改善线粒体功能和减少莱迪格细胞中氧化应激来增强的合成,并减少莱迪格细胞中的氧化应激
Meng-Li Liu1, Jia-Yu Wu2, Xi-Hui Sheng1
1Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Poultry science
|March 15, 2026
概括
亚斯丁 (ASTA) 通过增强线粒体功能和抗氧化能力,促进老化莱迪格细胞中的激素的产生. 这种天然化合物支持类固醇生成,并减少氧化应激,为男性生殖健康提供潜在的益处.
科学领域:
- 生殖生物学 生殖生物学
- 线粒体生理学线粒体生理学
- 营养学科学 营养学科学
背景情况:
- 的衰老导致丸激素的合成减少和莱迪格细胞功能受损.
- 氧化应激和线粒体功能障碍是导致与年龄相关的生殖能力下降的关键因素.
研究的目的:
- 为了研究阿斯塔克桑丁 (ASTA) 对合成和老化的丸莱迪格细胞中的线粒体功能的影响.
- 阐明ASTA影响类固醇生成,氧化应激和亡的机制.
主要方法:
- 来自老年的莱迪格细胞被用不同度的ASTA处理.
- 评估了莱迪格细胞活力,激素生产,mRNA和类固醇酶的蛋白质表达 (StAR,P450scc,3β-HSD,17β-HSD,SF-1).
- 评估了抗氧化酶活动 (SOD,CAT,GSH-PX),反应性氧物种 (ROS) 水平,氨酸 (MDA),线粒体膜潜力 (MMP),ATP含量和mtDNA复制数.
- 测量了线粒体生物发生调节剂 (PGC-1α,NRF1,TFAM) 和与亡相关的蛋白质 (Bcl-2,Bax,caspase-3,AIF) 的表达.
主要成果:
- ASTA显著增强了莱迪格细胞活力和的产生,在5μg/mL时产生最佳效果.
- 在ASTA上调节了关键的类固醇基因和抗氧化酶,同时降低了氧化应激标志物 (ROS,MDA).
- ASTA改善了线粒体功能 (MMP,ATP,mtDNA) 和生物发生,抑制了亡,并调节了与亡相关的蛋白质表达.
结论:
- 阿斯塔丁有效地增强老化的莱迪格细胞中的合成.
- 通过减轻氧化应激,改善线粒体功能和生物发生,调节类固醇生成途径,并抑制亡,ASTA发挥其作用.
- 这些发现凸显了ASTA作为治疗年龄相关男性生殖功能障碍的治疗剂的潜力.
相关概念视频
Testosterone: Functions and Regulation
2.8K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.8K
Electron Transport Chain: Complex I and II
19.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
19.4K
Mitochondria
21.2K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.2K
Muscle Recovery and Fatigue
4.7K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.7K
Functions of Thyroid Hormones
6.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.4K


