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Updated: Mar 17, 2026

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
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Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System

Published on: December 21, 2019

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在人工智能驱动下识别了一种选择性双重功能抑制剂,阻断HK2活性和HK2-VDAC1相互作用,在低氧条件下显示增强的抗癌疗效

Wenying Shan1, Shao-Lin Zhang2, Yehuda G Assaraf3

  • 1Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China; MoE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China.

European journal of medicinal chemistry
|March 15, 2026
PubMed
概括

一个新型的人工智能工具识别了化合物106,一种选择性六酶2抑制剂 (HK2i). 这种化合物通过阻断糖解和诱导癌细胞的亡,显示出作为抗癌疗法的前景.

关键词:
化合物-蛋白相互作用预测的预测.全球冠状病毒病毒 (GCVec)葡萄糖溶解是什么? 葡萄糖溶解氧气过低是因为缺氧.小分子抑制剂小分子抑制剂

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