血清瘤:在全球努力结束艾滋病毒死亡的缺失部分
Alessandro C Pasqualotto1, Thuy Le2, Tarsila Vieceli3
1Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil; Santa Casa de Porto Alegre, Porto Alegre, Brazil; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
The lancet. HIV
|March 15, 2026
概括
全球忽视了先进的艾滋病毒中的机会性感染 - - 血清性质瘤,这是一个机会性感染. 通过抗原测试进行早期诊断至关重要,但无法获得,这阻碍了结束与艾滋病毒有关的死亡的努力.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 公共卫生 公共卫生
背景情况:
- 血清性质是一种主要的机会性感染,并且是晚期艾滋病毒病患者的死亡原因.
- 这种曾经被认为仅限于美洲的真菌感染,现在在全球范围内得到认可,特别是在撒哈拉以南非洲和东南亚.
- 尽管它有影响,但在全球艾滋病毒应对中,胰腺血症仍然被忽视.
研究的目的:
- 在先进的艾滋病毒疾病的背景下,审查有关形体病的流行病学,诊断和治疗的当前知识.
- 突出诊断和治疗方面的挑战,并倡导增加诊断工具的研究和整合.
- 强调需要在全球艾滋病毒应对措施中终止对细胞质体的系统性忽视.
主要方法:
- 这篇综述综合了关于基因质等离子体流行病学,诊断和治疗的当前文献.
- 它评估了商业质体抗原测试对早期诊断的有用性.
- 它检查了当前的抗真菌治疗选择及其局限性.
主要成果:
- 诊断散布性细胞质瘤是一个重大挑战,往往导致误诊.
- 商业质体抗原测试为早期诊断提供了高灵敏度和特异性,但在全球范围内很少获得.
- 有限有效的抗真菌药物,包括安福特里辛B和伊特拉科纳,由于毒性和低于最佳的疗效/吸收,存在挑战.
结论:
- 迫切需要对研究进行投资,并将血清蛋白抗原查纳入先进的艾滋病毒治疗方案中,这是必不可少的.
- 拉丁美洲的监测,诊断扩展和标准化治疗模式为其他流行地区提供了一条途径.
- 解决被忽视的组织等离子体病的问题对于降低晚期艾滋病毒疾病的死亡率至关重要.
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