对联合AFT随机效应模型的处罚变量选择与集群竞争风险数据
1College of Economics Management, Weifang University of Science and Technology, Shouguang, China.
Pharmaceutical statistics
|March 15, 2026
概括
本研究引入了一种新的变量选择方法,用于用处罚h-likelihood对集群竞争风险数据进行选择. 模拟结果显示,SCAD和HL等处罚方法在准确的临床试验分析中优于LASSO.
科学领域:
- 生物统计学 生物统计学
- 临床试验 临床试验
- 生存分析的分析.
背景情况:
- 集群竞争风险数据在多中心临床试验中很常见.
- 集群中的事件发生使分析复杂化,需要考虑相关性的方法.
- 传统的基于危险的模型经常被使用,但生存时间分析提供了可解释性.
研究的目的:
- 为集群竞争风险数据的联合加速失效时间 (AFT) 模型中固定效应提出变量选择方法.
- 在这种情况下,评估惩罚h-likelihood (HL) 程序对变量选择的性能.
- 为了提高模型准确性,将处罚方法 (SCAD,HL) 与LASSO进行比较.
主要方法:
- 开发了一种使用惩罚性h-likelihood (HL) 方法的变量选择技术.
- 在因果特异的联合AFT随机效应建模框架中应用了该方法.
- 进行模拟研究以评估拟议方法的有效性.
主要成果:
- 被处罚的HL程序证明了对固定效应的有效变量选择.
- 模拟研究表明,处罚方法,特别是SCAD和HL,比LASSO更适合.
- 通过使用两个现实世界的临床数据集,成功说明了拟议的方法.
结论:
- 处罚h-likelihood方法提供了一个强大的方法,用于在联合AFT模型中对聚类竞争风险数据进行变量选择.
- 在这种情况下,处罚方法 (SCAD,HL) 与 LASSO 相比,在这种情况下提供了更高的性能.
- 开发的技术适用于真实临床数据分析,增强可解释性.
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