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没有被发现的入境,有被发现的传播:对中国第一类IB MPXV集群的流行病学见解

Xin Ye¹, Peng He^2,3,4, Baiyun Yu¹

¹Guangzhou Tianhe District Center for Disease Control and Prevention, Guangzhou 510655, Guangdong province, China.

The Journal of infectious diseases

|March 15, 2026

概括

克莱德Ibmpox可以从无症状的旅行者传播,尽管查结果为阴性. 加强监测和诊断对于控制mopox传播至关重要.

科学领域:

流行病学流行病学
病毒学病毒学
公共卫生公共卫生

背景情况:

由Ib类猿病毒 (MPXV) 引起的mopox疫情被宣布为国际关注的公共卫生紧急情况 (PHEIC).
中国在应对全球mopox疫情时实施了加强的监测措施.
一个没有症状的旅行者带有负面查测试启动了中国第一个clade Ib mpox传播集群.

研究的目的:

调查中国Ib杆菌群的传播模式.
描述mopox集群的临床,流行病学,环境和基因组特征.
为公众健康响应策略提供MPOX的信息.

主要方法:

进行了全面的流行病学,临床,环境和基因组调查.
使用定量PCR,血清学测试和人类和环境样本的全基因组测序.
评估病毒污染和确认mopox感染.

主要成果:

确定了四个流行病学相关的病例,包括一个进口指数病例和疑似第二代传播.
观察到有限的症状表现;两个病例有皮疹,一个有淋巴腺病,没有记录发烧.
通过全基因组测序确认了Ib类型的MPXV感染;MPXV在62个住宅环境样本中的25个中被检测到,但不是在公共场所.

结论:

尽管进入查结果为阴性,但Clade Ib mpox传染可能从无症状的个体发生.
仅仅基于症状或入口点的查不足以检测mpox.
加强基于风险的监测,诊断测试和有针对性的预防是控制mopox所必需的.

关键词:

集群集群是一个集群集群.流行病学调查流行病学调查一般联系人一般联系人异性传播是异性传播.MPXVMPXV MPXVVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPX 克拉德Ib亚系亚系亚系

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