光学连贯断层扫描血管学:系统性硬化症微血管病变的窗口
Martina Orlandi1, Tommaso Verdina2, Filippo Santoro1
1Rheumatologic Unit, Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
European journal of internal medicine
|March 15, 2026
概括
结核病患者表现出早期的眼球微血管病变,视网膜血管密度和长度降低,与毛细血管检查结果相关. 光学连贯断层扫描血管学 (OCTA) 揭示了系统性硬化症 (SSc) 中这些微血管病变的变化.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 在全身性硬化症 (SSc) 中观察到视网膜血管变化,这表明光学连贯断层扫描血管学 (OCTA) 可以评估与SSc相关的微血管病变.
- 在SSc中微血管病影响小血管,可能会影响视网膜健康.
研究的目的:
- 使用OCTA评估SSc患者视网膜中的微血管病变.
- 为了将这些视网膜变化与SSc.中的临床表现和毛细血管学发现相关联.
主要方法:
- 一项病例对照研究,将41名SSc患者与20名健康对照人进行比较.
- 在斑点和视神经中获得了表面和深层毛细血管 (SCP和DCP) 的OCTA扫描.
- 定量分析包括血管密度 (VD),血管长度密度 (VLD),状血管区域 (FAZ) 和视网膜厚度.
主要成果:
- 与对照组相比,SSc患者在SCP和DCP中显著减少了VD和VLD (p < 0.001).
- 在SSc患者 (p = 0.013) 中,观察到对状视网膜厚度的增加,与指甲折叠毛细管镜血流相关 (p = 0.030).
- 在DCP中,体静脉疾病和静脉疾病与无血管区域 (p = 0.018,p = 0.019) 和新血管生成 (p = 0.023,p = 0.025) 有关.
结论:
- 眼睛微血管病变是多发性硬化症患者的早期发现.
- 视网膜微血管病变的SSc与毛细血管学发现相关.
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