生物仿真剂和牙重矿化的类型:范围审查和功能分类
Gabriela de Alencar Pinto Magalhães1, Laryssa Mylenna Madruga Barbosa2, Samara Lavínnya Serrano de Souza Araújo3
1Department of Restorative Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia, 30912, USA.
概括
仿生药物显示出对牙和牙的重矿化有希望,按其作用进行分类. 然而,大多数证据都是体外的,因此需要进行临床试验以验证治疗效果.
科学领域:
- 生物材料科学 生物材料科学
- 牙科研究 牙科研究
- 再生医学是一种再生医学.
背景情况:
- 牙损仍然是一个重要的全球健康问题.
- 再矿化策略的目的是恢复矿物质含量去矿化牙结构.
- 生物仿真剂为模仿自然生物矿物化过程提供了新的方法.
研究的目的:
- 为了绘制和分类生物仿真剂,以使牙和牙重矿化.
- 根据成分和作用机制对药物进行分类.
- 确定该领域的证据水平和研究缺口.
主要方法:
- 根据PRISMA指南进行范围审查.
- 进行全面的数据库搜索 (PubMed/MEDLINE,Scopus,Embase,科学网).
- 包括将仿生材料直接应用于质/牙的研究.
主要成果:
- 82项研究符合资格标准,其中以体外研究为主 (73项研究).
- 仿生剂分为四种机械类别:自组装模板,离子结合导体,生物聚合物支架和直接矿化剂.
- 乳重矿化研究更频繁 (56项研究) 比牙 (26项研究);常见的结果包括机械性质的恢复和矿物质的增加.
结论:
- 建立了牙重矿化生物仿真剂的结构化框架.
- 目前的证据基础主要是体外.
- 进一步的精心设计的临床试验对于验证这些药物的治疗疗效至关重要.
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