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新型动物传染病和多药耐药性Streptococcus suis血统的出现

Jaime Brizuela¹, Gemma G R Murray², Parichart Boueroy³

¹Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

|March 15, 2026

概括

新兴的多药耐药性Streptococcus suis谱系CC104和CC233通过基因组区域转移迅速演变. 这些菌株构成重大威胁,原因是它们对人类和猪治疗中使用的关键抗生素具有耐药性.

科学领域:

微生物学微生物学
基因组学就是基因组学.
进化生物学是进化的生物学.

背景情况:

在东南亚,Streptococcus suis是成年人细菌脑膜炎的主要原因,通常与生猪肉消费有关.
在全球范围内,动物性感染的S. suis感染通常是由CC1血统菌株引起的,其血清型为2囊.
在泰国,同样具有血清型2囊的特有血统CC104和CC233,占动物感染的很大一部分.

研究的目的:

调查泰国S. suis血统CC104和CC233.3出现背后的进化驱动因素.
了解这些血统中动物感染潜力和多药耐药性的获得.

主要方法:

141个泰国S. suis菌株的全基因组测序 (15年期间).
与2761个S. suis基因组的全球数据集的整合.
比较基因组学,贝叶斯进化模型和多变量分析.

主要成果:

CC104在1990年左右出现,CC233在2002年左右出现,通过囊位置切换从CC1获得血清型2囊.
这两种血统都获得了多种抗微生物耐药性 (AMR) 决定因素,其中一些菌株对八种抗生素类别有耐药性.
CC104和CC233是第一个表现出对青素和 ceftriaxone,人类治疗关键抗生素的耐药性增加的动物性病菌系.

结论:

横向基因转移促进了多药耐药性动物性感染性S. suis.的快速出现.
由于AMR的增加,迫切需要加强监测,感染控制和S. suis的替代治疗方法.

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