对精神分裂症的遗传易感性和青春期大脑发育变化的出现
Bing Xu1, Annet Dijkzeul1, Yingzhe Zhang2
1Department of Child and Adolescent Psychology and Psychiatry, Erasmus MC, University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
精神分裂症的遗传风险可能会影响青春期早期的大脑发育,显示出不同的轨迹. 教育成就和ADHD的多基因分数也随着时间的推移与大脑形态有关.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 了解精神病理学的遗传脆弱性的早期神经发育迹象是早期干预的关键.
- 在大脑中遗传风险表现的精确时间尚未得到充分理解.
研究的目的:
- 研究精神疾病和教育成就的多基因分数如何影响神经发育期间的大脑形态轨迹.
- 根据遗传易感性和大脑发育来确定精神疾病的潜在早期生物标志物.
主要方法:
- 利用来自两个大型神经发育队列 (ABCD研究和R世代研究) 的数据.
- 分析了6229名 (平均年龄为10岁) 个体的重复测量脑成像数据,使用 vertex-wise线性混合模型.
- 检查了多基因ADHD,自闭症,精神分裂症,严重抑郁症和教育成就与大脑形态学随时间推移的多基因分数之间的关联.
主要成果:
- 具有较高遗传易感性精神分裂症的个体在青春期早期表现出前额区域皮质表面积的减少,与易感性较低的个体形成对比.
- 教育成就的较高的多基因分数与持续更大的表面积有关.
- 较高的注意力缺陷/多动症 (ADHD) 多基因分数与前额叶和叶的表面积持续较小有关.
结论:
- 对精神分裂症的遗传易感性可能在青春期早期在大脑中表现出来,这表明神经发育的动态变化.
- 这些发现表明,早期诊断精神分裂症的潜在生物标志物.
- 教育成就和ADHD的多基因分数也显示了与长期大脑形态模式的关联.
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